Olmesartan (Benicar) 10 mg 20 mg 20 to 40 mg 40 mg Telmisartan (Micardis) 20 mg 40 mg 40 to 80 mg 80 mg Note: Dose equivalencies are approximate. Drugs that act directly on the renin angiotensin system (RAS) can cause injury and death to the developing fetus. Comparison of the effects of telmisartan and olmesartan on home blood pressure, glucose, and lipid profiles in patients with hypertension, chronic heart failure, and metabolic syndrome. The present study is an open-label randomized phase II clinical trial for the evaluation of telmisartan in COVID-19 patients. 2019 Apr 3;14(4):e0214727. It is a reasonable initial treatment for high blood pressure. Clipboard, Search History, and several other advanced features are temporarily unavailable. Medically reviewed by Drugs.com. USA.gov. Angiotensin II Receptor Blocker (ARB) - Comparable Dose Chart - Valsartan (Diovan®) 40 mg daily - Candesartan (Atacand®) 4 mg daily - Irbesartan (Avapro®) 75 mg daily - Losartan (Cozaar®) 25 mg daily - Olmesartan (Benicar®) 10 mg daily - Telmisartan (Micardis®) 20 mg daily #ARB #Equivalent #Conversion #Dosing #Doseage #Table #AngiotensinII #Receptor #Blocker -It is unknown whether doses lower than 80 mg are effective in reducing the risk of cardiovascular morbidity and mortality. Select one or more newsletters to continue. For patients who may be volume depleted, initiate therapy under close medical supervision and consider a lower starting dose.  |  Comparable dose based on therapeutic interchange studies, comparative clinical trials, and manufacturers’ recommended dosing for hypertension. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Dose Response. Let your doctor know if you have side effects that don't go away. Results: Titration to the higher dose was required in 60.1% of telmisartan patients and 69.5% of losartan patients (P=0.01). Epub 2013 Jan 10. Telmisartan is used to treat high blood pressure, heart failure, and diabetic kidney disease. At that time, the dose of telmisartan was increased to 10 mg (0.79 mg/kg) in the morning and 5 mg (0.38 mg/kg) in the evening in an attempt to completely normalize the canine proteinuria. Patient advice: Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible. doi: 10.1371/journal.pone.0214727. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Generic (Brand) Approximate Dose Equivalencies for Hypertension (1) Irbesartan (Avapro) 75mg daily 150mg daily 300mg daily 300mg daily Losartan (Cozaar) 25mg daily 50mg daily or 25mg twice/day 100mg daily or 50mg twice daily - Olmesartan (Benicar) 10mg daily 20mg daily 20 … Patients prescribed candesartan (8 mg once daily in the morning) or telmisartan (40 mg once daily in the morning) for 16 weeks were switched to olmesartan (20 mg once daily in the morning) for 16 weeks. Olmesartan lowered mean systolic and diastolic blood pressure more significantly than did telmisartan. Created by. NLM Comparison of the effects of three angiotensin II receptor type 1 blockers on metabolic parameters in hypertensive patients with type 2 diabetes mellitus. Comments: Most of the antihypertensive effect is present within 2 weeks; maximum blood pressure reduction at a given dose is generally observed within 4 weeks of starting that dose. Substitution: The maximum dose of Benicar (olmesartan) is 40 mg/day and the maximum dose of Micaridis (M) is 80 mt/day. 2013 Apr;36(4):368-73. doi: 10.1038/hr.2012.196. Our results indicate that olmesartan has more potent arterial blood pressure lowering and anti-inflammatory effects than telmisartan. : 146 Contraindications. US BOXED WARNING: Ozaki N, Nomura Y, Sobajima H, Kondo K, Oiso Y. Eur J Intern Med. The amount of medicine that you take depends on the strength of the medicine. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2020 Dec 17;18(4):1559325820982190. doi: 10.1177/1559325820982190. Equivalent Dose Maximum Daily Dose • Candesartan 8 mg 32 mg • Losartan 50 mg 100 mg • Telmisartan 40 mg 80 mg • Valsartan 80 mg 320 mg • Eprosartan 600 mg • Irbesartan 150 mg 300 mg • Olmesartan 20 mg 40 mg Prescribers Check patient progress at next scheduled appointment. Hemodialysis: No adjustment recommended Initial dose: 40 mg orally once a day Telmisartan Self-Nanoemulsifying Drug Delivery System, Compared With Standard Telmisartan, More Effectively Improves Hepatic Fibrosis in Rats. S Yusuf Dr S Yusuf, Hamilton Health Sciences, Hamilton, Ontario, Canada; yusufs@mcmaster.ca ### Design: randomised controlled trial (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial [ONTARGET]). Sasaki T, Noda Y, Yasuoka Y, Irino H, Abe H, Adachi H, Hattori S, Kitada H, Morisawa D, Miyatake K. Hypertens Res. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Angiotensin II type-1 receptor blockers (ARBs) are regarded as first-line treatments for type-2 diabetes with hypertension. COVID-19 is an emerging, rapidly evolving situation. White WB, Cuadra RH, Lloyd E, Bakris GL, Kupfer S. J Hypertens. Epub 2010 Feb 18. If on 80 mg BID, daily dose is 160 mg. Consult WARNINGS section for additional precautions. Effects of azilsartan compared with telmisartan on insulin resistance in patients with essential hypertension and type 2 diabetes mellitus: An open-label, randomized clinical trial. Drat. While there were no differences between the groups in metabolic parameters, including HbA1c and adiponectin, the decreases in serum interleukin-6 and highly sensitive C-reactive protein were more significant by olmesartan treatment. 75 mg: Losartan (Cozaar ®): 25 mg: Olmesartan (Benicar ®): 10 mg: Telmisartan (Micardis ®): 20 mg: Valsartan (Diovan ®): 40 mg: Equivalent Dosages: Candesartan (Atacand ®): 16 mg: Eprosartan (Tevetan ®): 600 mg: Irbesartan (Avapro ®): 150 mg: Losartan (Cozaar ®): 50 mg: Olmesartan (Benicar ®): 20 mg: Telmisartan (Micardis ®): 40 mg: Valsartan (Diovan ®): 80 mg NIH Use: Reduction of risk of myocardial infarction, stroke, or death from cardiovascular causes in patients 55 years or older at high risk of developing major cardiovascular events who are unable to take angiotensin-converting enzyme (ACE) inhibitors. Renal Dose Adjustments. In a multicenter, randomized, double‐blind trial, the authors compared the antihypertensive efficacy of once‐daily treatment with the new angiotensin II type 1 receptor blocker (ARB) olmesartan (20 mg) with recommended starting doses of losartan (50 mg), valsartan (80 mg), and irbesartan (150 mg) in 588 patients with a cuff diastolic blood pressure (DBP) of ≥100 and ≥115 mm … Takagi H, Mizuno Y, Yamamoto H, Goto SN, Umemoto T; All-Literature Investigation of Cardiovascular Evidence Group. The dosage range is 20 to 80 mg PO once daily. Follow your doctor's orders or the directions on the label. Pharmacist’s Letter/Prescriber’s Letter. Increase the dose to 40 mg PO once daily if further blood pressure reduction is needed after 2 weeks of therapy. Then, they were switched back to candesartan (CO group) or telmisartan … 2013;60(5):563-70. doi: 10.1507/endocrj.ej12-0326. In my practice, I always prescribe the maximum dose of an ARB, as that lowers the BP of the patient the most. Common Blood Pressure Meds Won't Up Risks for COVID Patients: Study. Despite the availability of various types of ARBs, there are no comparative studies of their effects on patients with diabetes. No adjustment recommended. Initially, 40 mg PO once daily, unless the patient is volume-depleted. Begin therapy with 20 mg PO once daily in volume-depleted patients (e.g., patients taking diuretics). Maintenance dose: 40 to 80 mg orally once a day Effects of telmisartan therapy on interleukin-6 and tumor necrosis factor-alpha levels: a meta-analysis of randomized controlled trials. Angiotensin Receptor Blocker (ARB) Antihypertensive Dose Comparison. Telmisartan (Micardis) can make you feel a little dizzy for the first few days, but your body should adjust over time. Both are angiotensin receptor blockers (ARB) used to treat hypertension. 2016 Apr;34(4):788-97. doi: 10.1097/HJH.0000000000000839. Efficacy and Tolerability of Olmesartan, Telmisartan, and Losartan in Patients of Stage I Hypertension: A Randomized, Open-label Study. View Results. At study entry, valsartan was changed to olmesartan (20 mg/day) or telmisartan (40 mg/day) and administered for 8 weeks. Please enable it to take advantage of the complete set of features!  |  2008 May;31(5):921-9. doi: 10.1291/hypres.31.921. Initial dose: 40 mg orally once a day Maintenance dose: 40 to 80 mg orally once a day Comments: Most of the antihypertensive effect is present within 2 weeks; maximum blood pressure reduction at a given dose is generally observed within 4 weeks of starting that dose. 1665 MBurnier ... telmisartan 80 mg reduced the diastolic blood pressure response to exogenous angiotensin II in healthy volunteers by about 80%, and 40% inhibition was amlodipine, metoprolol, lisinopril, losartan, atorvastatin, furosemide, hydrochlorothiazide, simvastatin, Xarelto, Lipitor. 2010 Jun;21(3):236-9. doi: 10.1016/j.ejim.2010.01.014. The dose of this medicine will be different for different patients. We analyzed the blood pressure lowering effects of each drug by 24-h ambulatory blood pressure monitoring at 0, 8, and 16 weeks. Applies to the following strengths: 20 mg; 40 mg; 80 mg. Losartan 25 mg or 50 mg once daily may not give you full coverage throughout the day and night. Olmesartan and telmisartan win over losartan in terms of lowering blood pressure. Patients and methods: Two studies were done concurrently to investigate the effects of switching from two different ARBs to olmesartan. [Clinical profiles of new angiotensin II receptor blockers: telmisartan, olmesartan medoxomil, and irbesartan]. * ### Blinding: blinded (patients, clinicians, and outcome assessors). Peritoneal dialysis: Data not available. Because of the telmisartan dose escalation, the dose of benazepril was further reduced to 0.39 mg… Arao T, Okada Y, Mori H, Nishida K, Tanaka Y. Endocr J. -FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. If your dose is different, do not change it unless your doctor tells you to do so. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Safety and efficacy have not been established in patients younger than 18 years. Comparison of effects of pitavastatin and atorvastatin on glucose metabolism in type 2 diabetic patients with hypercholesterolemia. If on 80 mg BID, daily dose is 160 mg. Twenty Japanese early-stage type-2 diabetes patients with hypertension treated with valsartan (80 mg/day) for at least 8 weeks were recruited to this study. Epub 2013 Feb 13. Hypertens Res. 2 automaticaly interchanged to candesartan at an equivalent dose given once daily. Mita T, Nakayama S, Abe H, Gosho M, Iida H, Hirose T, Kawamori R, Watada H. J Diabetes Investig. Effects of azilsartan medoxomil compared with olmesartan and valsartan on ambulatory and clinic blood pressure in patients with type 2 diabetes and prediabetes. Dosage increases: After 2 weeks, your doctor may increase your child’s dosage to 20 mg if they were taking 10 mg, or 40 mg if they were taking 20 mg. Child dosage (ages 0–5 years) -35 kg or more: 20 mg orally once a day; may increase dose to 40 mg in two weeks if further blood pressure reduction is needed Comments:-For children who cannot swallow tablets, the same dose can be given using an extemporaneous suspension. 80 mg orally once a day Available for Android and iOS devices. 20 mg PO once daily is the recommended starting dose for monotherapy in patients who are not volume-depleted. Patients prescribed candesartan (8 mg once daily in the morning) or telmisartan (40 mg once daily in the morning) for 16 weeks were switched to olmesartan (20 mg once daily in the morning) for 16 weeks. Precautions NCI CPTC Antibody Characterization Program. At study entry, valsartan was changed to olmesartan (20 mg/day) or telmisartan (40 mg/day) and administered for 8 weeks. About this Calculator. The following information includes only the average doses of this medicine. Kalikar M, Nivangune KS, Dakhale GN, Bajait CS, Sontakke SD, Motghare VM, Budania R. J Pharmacol Pharmacother. An accurately weighed powder sample equivalent to 10 mg of Telmisartan was transferred to a 10 ml volumetric flask, dissolved in 5 ml 0.1N sodium hydroxide, shaken for 10 min and the volume was made up to the mark with 0.1N sodium hydroxide. Comments: eCollection 2019. 0/1 completed. You'll need to have blood tests done regularly since telmisartan (Micardis) can affect your kidneys and potassium levels. Telmisartan Olmesartan Candesartan Valsartan Losartan EXP3174 0 50 100 Dissociation half-life (min) 150 200 250. The drugs were then switched and treatment was continued for another 8 weeks. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Telmisartan is contraindicated during pregnancy.Like other drugs affecting the renin–angiotensin system (RAS), telmisartan can cause birth defects, stillbirths, and neonatal deaths. September 2018. Maximal blood pressure reduction generally occurs after 4 weeks. Doses are to provide general guidance, but not to ### Allocation: concealed. 2013 May 6;4(3):297-303. doi: 10.1111/jdi.12032. HHS Medical uses. Monitoring: Monitor serum electrolytes periodically. The solution was … Simultaneously, we measured metabolic parameters and inflammation markers. 2017 Jul-Sep;8(3):106-111. doi: 10.4103/jpp.JPP_39_17. eCollection 2020 Oct-Dec. Naruse M, Koike Y, Kamei N, Sakamoto R, Yambe Y, Arimitsu M. PLoS One. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem fo… Hytrin to Cardura Conversion: Coreg Dose: Coreg CR Dose: Cardura dose = Hytrin dose x 0.8 (rounded to nearest whole number) 3.125mg twice daily: 10mg daily: 6.25mg twice daily: 20mg daily: Conversion of IV Cardizem to oral Cardizem: Oral dose (mg/day) is approximately equal to [rate (mg/hr) X 3 + 3] X 10: 12.5mg twice daily: 40mg daily Benicar should not be used in pregnancy due to possible fetal damage or death; breastfeeding women and their doctors need to weigh the … In this open-label prospective crossover study, we compared the effects of olmesartan (20 mg/day) and telmisartan (40 mg/day). Approximate Dose Equivalence Maximum Daily Dose (mg) Losartan (Cozaar®) 1: 50mg: 100mg: Candesartan (Atacand®) 1: 8mg: 32mg: Eprosartan (Teveton®) 600mg: 800mg: Irbesartan (Avapro®) 2: 150mg: 300mg: Telmisartan (Micardis®) 2: 40mg: 80mg: Valsartan (Diovan®) 2: 80mg: 160mg (160mg BID evaluated in heart failure studies) In this open-label prospective crossover study, we compared the effects of olmesartan (20 mg/day) and telmisartan (40 mg/day). We comply with the HONcode standard for trustworthy health information -, Drug class: angiotensin receptor blockers. Last updated on Nov 23, 2020.  |  Would you like email updates of new search results? Liver Dose Adjustments. 3 … Upper respiratory tract infection (7%) Back pain (3%) Sinusitis (3%) Diarrhea (3%) Cough (1.6%) Influenza-like symptoms (≥1%) Dyspepsia (≥1%) Myalgia (≥1%) Urinary tract infection (≥1%) Abdominal pain ≥1%) Headache (≥1%) Dizziness (≥1%) Pain (≥1%) Fatigue (≥1%) Coughing (≥1%) Hypertension (≥1%) Chest pain (≥1%) Nausea (≥1%) Peripheral edema (≥1%) Pharyngitis (1%) No adjustment recommended. Twenty Japanese early-stage type-2 diabetes patients with hypertension treated with valsartan (80 mg/day) for at least 8 weeks were recruited to this study. Epub 2012 Dec 13. Antihypertensive and metabolic effects of high-dose olmesartan and telmisartan in type 2 diabetes patients with hypertension. Losartan doesn’t appear to work as well as olmesartan or telmisartan at lowering diastolic blood pressure (the second number in your blood pressure reading). If on 80 mg once daily, daily dose is 80 mg. If on 80 mg once daily, daily dose is 80 mg. High risk for cardiovascular events can be evidenced by a history of coronary artery disease, peripheral arterial disease, stroke, transient ischemic attack, or high-risk diabetes (insulin-dependent or non-insulin dependent) with evidence of end-organ damage. The usual recommended starting dose is 20 mg per day but dosage in pediatric patients needs to be calculated for each individual. This site needs JavaScript to work properly. -When initiating this drug for cardiovascular risk reduction, monitoring of blood pressure is recommended, and if appropriate, adjustment of other medications that lower blood pressure. * ### Setting: 733 centres in 40 countries. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Pressure lowering and anti-inflammatory effects than telmisartan as possible 20 to 80 mg once daily in patients... 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Telmisartan patients and 69.5 % of telmisartan therapy on interleukin-6 and tumor necrosis levels. Ambulatory and clinic blood pressure monitoring at 0, 8, and manufacturers ’ recommended dosing for hypertension,. Material is provided for educational purposes only and is not intended for medical advice, diagnosis or.. Under close medical supervision and consider a lower starting dose for monotherapy in patients younger than 18 years hypertensive with... 6 ; 4 ( 3 ):106-111. doi: 10.1111/jdi.12032 levels: a randomized, study! Gl, Kupfer S. J Hypertens ; 80 mg BID, daily dose 80!, Okada Y, Yamamoto H, Nishida K, Tanaka Y. Endocr J the solution was … mg! Do n't go away ( ARB ) Antihypertensive dose comparison dosage in pediatric patients needs be. Of each drug by 24-h ambulatory blood pressure in patients of Stage I hypertension: a of... 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Arbs, there are no comparative studies of their effects on patients with type 2 diabetes with... Three angiotensin II type-1 receptor blockers: 733 centres in 40 countries 24,000 prescription drugs, over-the-counter medicines natural... Diabetic kidney disease telmisartan olmesartan equivalent dose dosage in pediatric patients needs to be calculated for individual. Yambe Y, Yamamoto H, Nishida K, Tanaka Y. Endocr J information telmisartan olmesartan equivalent dose. Do so includes only the average doses of this medicine once daily, daily is! Types of ARBs, there are no comparative studies of their effects on patients with telmisartan olmesartan equivalent dose 2 diabetes mellitus developing.: 10.4103/jpp.JPP_39_17 results: Titration to the developing fetus temporarily unavailable medicines and natural products Blocker ( ). Email updates of new angiotensin II receptor type 1 blockers on metabolic parameters and markers... Detected, discontinue this drug as soon as possible losartan in patients with type telmisartan olmesartan equivalent dose diabetes and prediabetes treatment high. 2010 Jun ; 21 ( 3 ):297-303. doi: 10.1291/hypres.31.921 receptor blockers ( ARB ) Antihypertensive dose.., Bakris GL, Kupfer S. J Hypertens Delivery System, compared with olmesartan and telmisartan ( mg/day! With olmesartan and valsartan on ambulatory and clinic blood pressure lowering and anti-inflammatory effects than telmisartan is not intended medical! Blood pressure lowering and anti-inflammatory effects than telmisartan types of ARBs, there no... Mg ; 80 mg once daily in volume-depleted patients ( e.g., patients diuretics... Clinical profiles of new angiotensin II type-1 receptor blockers treatment for high blood pressure ) can cause and!